01-08-2015, 08:28 AM   #1
Senior Member
Lam123's Avatar

How long does it take for Imuran to start working? And once you stop it, how long does it take to leave your system?
Crohns for 26 years
Previous meds: Pentasa, Imuran
Current meds:
Humira weekly
- multi vitamin and vitamin D
- B12 shots monthly
Mother of one beautiful boy and a puppy! 👪🐶Happily married to an amazing and patient man, that I call my best friend❤️I'm just living life one day at a time and trying to figure out this crazy disease! 🍀🌞⭐️
01-08-2015, 09:06 AM   #2
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2thFairy's Avatar
Join Date: Sep 2010
Location: Dallas, Texas

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It can takes up to a couple of months to feel the full effects. I don't know how long (or short) it takes to clear your system when you stop taking it, but I had pancreatitis secondary to Imuran and I felt significantly better 48 hours after stopping it.
Ulcerative colitis

Total colectomy with ileostomy featuring Sideshow Bob since January 2012

"The colon seems an unlikely candidate for dramatic effect, but now and then it serves that purpose well." The Associated Press Guide to Punctuation
01-08-2015, 10:51 AM   #3
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alex_chris's Avatar
Join Date: Apr 2013
Location: Frankfurt, Germany
The effect on Crohn's is determined by a controlled suppression of the immune system and depends on how long white blood cells on average live (several weeks) in the particular human AND on that individual's reaction to a certain dosage of azathioprine (imuran) as well as how regularly the individual takes the drug (e.g. non-conformance of patient, that is disregarding when and how to take a dosage). It usually, as said above, takes 2-3 months.

The effect is not a "switch" in that after a certain time, the person just feels good. Azathioprine only helps a patient to manage Crohn's, but a detrimental way of living (eating in a way detrimental to Crohn's, heavy alcohol consumption, tobacco use, no sport, stress etc.) will in most cases "overpower" the useful effect of azathioprine. These patients usually report that azathioprine did not help them stay in remission. Also, azathioprine has not been determined to have any statistically significnt benefit to induce remission in patients with active Crohn's (that is why steroids are required; or biologics are used to induce remission).

Regarding "leaving the system", azathioprine is to an extent of 90% absurbed directly by the gut. The highest blood plasma concentrations are one to two hours after taking it, depending on the patient and the average plasma half-life (once it reaches the blood) is 20 to 80 minutes for azathioprine and 3 to 5 hours for its metabolites (principally 6-mp). 20 to 30% are bound to plasma proteins while circulating in the bloodstream. Having said all that, after 3 times the half life and considering the original intake, after 12 hours, most orally taken azathioprine has left the system and after 24 hours, the system as returned principally to normal. This is also the reason, why aza should be taken in the morning and the evening and not just one time per day, each time at the same dosage.
Crohn's diagnosed in 1999
On Aza from 2003 to 2008 and from 2010 again until Today
60cm of smaller intestine removed in 2003
Vitamin therapy with D3, B6, B12, magnesium, zinc, folic acid for years
Iron therapy with Tardyferron 80mgx2 and Loesferron 80mg for years
Yoga, running, freeletics on the sport side!
01-08-2015, 12:02 PM   #4
Senior Member
Lam123's Avatar
Thank you for the great info, I really appreciate it.

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