Crohn's Disease Forum » Treatment » Vitamin D Fights Crohn's Disease

04-20-2015, 12:47 AM   #1
Join Date: Dec 2014
Location: Bremerton, Washington
Vitamin D Fights Crohn's Disease

This discussion focuses on vitamin D3 as a treatment for CD and UC and not just a dietary supplement.

Researchers found that vitamin D3 acts directly on the beta defensin 2 gene, which encodes an antimicrobial peptide, and the NOD2 gene that alerts cells to the presence of invading microbes.

Both beta defensin and NOD2 have been linked to Crohn's disease. If NOD2 is deficient or defective, it cannot combat invaders in the intestinal tract.

Science has known for some time of the importance of vitamin D in the treatment of inflammatory bowel diseases like Crohn's and ulcerative colitis. I posted a study on this ten years ago.

In my view it is reprehensible and irresponsible not to measure the levels of vitamin D in patients with this disease. You need to measure the vitamin D level in your blood, as it is virtually impossible to simply know whether or not it is in the therapeutic levels of 55 to 65 ng/ml.

If you or someone you know has this disease, please beg them to get their vitamin D level monitored. Most adults need at least 5000 units per day, but some may actually require up to 50,000 units per day. There is just no way of knowing without measuring.


Have you had a lab test for 25(OH)D?

Have you had your kids tested for 25(OH)D to see if they are vitamin D3 deficient?

The normal reference range for 25(OH)D is 30 to 100 ng/mL, (75 to 250 nmol/L). If your 25(OH)D is ≤30 ng.mL you're vitamin D3 deficient. People with a vitamin D3 deficiency are frequently deficient in magnesium. VitaminDWiki lists over 50 studies indicating nearly all people with CD and UC are vitamin D3 deficient.

Crohn's can be classified as a genetotrophic disease. Diseases which result from genetically determined nutritional metabolic needs not being met by the individual and which result in poor gene expression. Examples of genetotrophic diseases include Scurvy is caused by a lack of vitamin C. Sailors from England used to take crates of limes with them on long ocean voyages to prevent this disorder and came to the new world sucking on limes to prevent scurvy… and that’s why they’re called “Limeys.” Another example is Rickets. It’s caused by a lack of vitamin D3 or the inability to pull calcium from the GI tract. An iodine deficiency can lead to enlargement of the thyroid a.k.a. goiter. Beriberi is a disease brought on by a Vitamin B-1 (thiamine) deficiency. There are many other diseases that meet the definition of a genetotrophic disease.

Do you take at least 5000 IU/day of vitamin D3 to treat your CD or UC?
It costs less than six cents a day.

Take care,

V/R, Batch
04-22-2015, 01:03 AM   #2
Jeffgotcrohns's Avatar
Join Date: Apr 2013
Location: Hudson, Ohio

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Thanks for taking the time to post. Wonder why no one has responded. Most people are vitamin D deficient and the above post makes sense. Worth a try for anyone suffering from IBD.
04-22-2015, 01:40 PM   #3
Join Date: Mar 2015
Location: Reims, France
The real deal is :

Can D3 make remission ? 5000 ui is sufficent , or more ?
Don't forget that large D3 amount can be very toxic !!!

Maybe D3 and DHEA could be a good thing!

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