Crohn's Disease Forum » Parents of Kids with IBD » How what we eat can affect the gut - crohns

11-22-2016, 08:15 AM   #1
my little penguin
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How what we eat can affect the gut - crohns

The incidence of autoimmune diseases is increasing along with the expansion of industrial food processing and food additive consumption.

The intestinal epithelial barrier, with its intercellular tight junction, controls the equilibrium between tolerance and immunity to non-self-antigens. As a result, particular attention is being placed on the role of tight junction dysfunction in the pathogenesis of AD. Tight junction leakage is enhanced by many luminal components, commonly used industrial food additives being some of them.

Glucose, salt, emulsifiers, organic solvents, gluten, microbial transglutaminase, and nanoparticles are extensively and increasingly used by the food industry, claim the manufacturers, to improve the qualities of food. However, all of the aforementioned additives increase intestinal permeability by breaching the integrity of tight junction paracellular transfer. In fact, tight junction dysfunction is common in multiple autoimmune diseases and the central part played by the tight junction in autoimmune diseases pathogenesis is extensively described. It is hypothesized that commonly used industrial food additives abrogate human epithelial barrier function, thus, increasing intestinal permeability through the opened tight junction, resulting in entry of foreign immunogenic antigens and activation of the autoimmune cascade. Future research on food additives exposure-intestinal permeability–autoimmunity interplay will enhance our knowledge of the common mechanisms associated with autoimmune progression.

Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease
Aaron LernerTorsten Matthias

DS - -Crohn's -Stelara -mtx
11-24-2016, 01:17 PM   #2
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Interesting article.

Crohn's Dx'ed Sept 08
Allerg Imuran Sept 08
Fail Remicade Jan 09
Methotrex Oct 09-Aug 11
Pentasa stopped - nosebleeds
EENOct 31 - Nov 28th. Too hard!
Retried Remicade Dec 11
Stopped due 2 Anaphylactic Reaction
LDN Jan 2012-June 2014 Got My daughter back!
New secondary diagnosis: Gastroporesis Dec 2013
Lost remission June 2014
Started Entyvio April 2015. Decreased to every 4 weeks October 2015. Praying for remission.
11-24-2016, 01:39 PM   #3
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Very interesting. Odd that salt is one of the culprits, considering it's been used for a very long time. Maybe because there's so much in processed foods? It makes me wonder about whether it played a part in my dad's Crohns - I've never known anyone who used as much salt as he did, to the extent that none of us could eat what he cooked (though he'd happily sprinkle extra table salt on top of what was already barely edible!)

Crohn's Disease Forum » Parents of Kids with IBD » How what we eat can affect the gut - crohns
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