Crohn's Disease Forum » Parents of Kids with IBD » Capsule Endoscopy vs MRE

03-06-2018, 10:50 AM   #1
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Capsule Endoscopy vs MRE


Comparison of Capsule Endoscopy and Magnetic Resonance Enterography for the Assessment of Small Bowel Lesions in Crohn’s Disease
Begoña González-Suárez, MD, PhD Sonia Rodriguez, MD Elena Ricart, MD, PhD Ingrid Ordás, MD, PhD Jordi Rimola, MD, PhD Álvaro Díaz-González, MD Cristina Romero, MD Cristina Rodríguez de Miguel Arantxa Jáuregui, MD Isis K Araujo, MD ... Show more
Inflammatory Bowel Diseases, izx107,
Published: 01 March 2018 Article history
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Background and Aims
Diagnostic yield of Small Bowel Capsule Endoscopy (SBCE) for the assessment of small bowel (SB) lesions is higher than radiologic imaging techniques. However, magnetic resonance enterography (MRE) data are scarce and inconclusive. Colon Capsule Endoscopy (CCE) is a new capsule modality. The primary aim of our study was to compare MRE and capsule endoscopy (CE) for the assessment of Crohn’s disease (CD). The secondary objectives were to compare the diagnostic accuracy of both CE modalities and changes in Montreal classification after each examination.
We included 47 patients with established (n = 32) or suspected CD (n = 15). MRE was performed first to rule out strictures. In patients with a suspected stricture by MRE, an Agile Patency Capsule was performed. SB disease activity was measured by MaRIA score (MRE) and Lewis Index (CE).
SB lesions were found in 36 of47 patients with CE and in 21 of47 patients with MRE (76.6% vs 44.7%, P = 0.001). Jejunal inflammation was detected by CE in 31.9% of patients and by MRE in 6.4% of patients (15/47 vs 3/47; P = 0.03); lesions in ileum were detected in 57.4% of patients by CE, and in 21.3% of patients by MRE (27/ 47 vs 10/ 47; P = 0.04). Finally, in terminal ileum, CE showed lesions in 68.1% (32/47) of patients, whereas MRE detected lesions in 38.3% (18/ 47 patients), (P = 0.001). The original Montreal classification was changed in 53.1% of patients (25/ 47) based on CE findings and in 12.7% of patients (6/47) based on MRE findings (P < 0.05).
In our cohort CE was significantly superior to MRE for detecting SB lesions, mainly superficial and proximal lesions. CE is useful for a appropriate patients’ classification according to Montreal classification.
Daughter O dx 2/1/12 at age 12
Crohns & Remicade induced Psoriasis
Vit d 2000IU
Multi vitamin plus iron

Previously used - Prednisone, Prevacid, Enteral Nutrition, Methotrexate oral and injections, Folic Acid, Probiotics, Cortofoam

Daughter T dx 1/2/15 at age 11
Vitaligo, Precoscious puberty & Crohn's
Vit D 2000IU

Previously used, Exclusive Enteral Nutrition, Methotrexate (injections and oral), Folic Acid, Entocort,IBD-AID Diet
03-06-2018, 12:08 PM   #2
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Thanks for posting that--really interesting.
Daughter E (15) dx with Crohn's 12/18/14 at age 12

Current treatment:

Remicade started 12/24/14 (9 mg/kg every 6 weeks)
Oral methotrexate restarted 12/2/16 (20 mg weekly)
vitamin D, folic acid, iron, multivitamin, Prozac

Past Treatment
90% EN via NG tube 2/9/15 - 4/2/15
50% EN via NG tube 4/3/15 - 4/18/15
Supplemental EN via NG tube 5/7/15-6/19/15
Budesonide 3/3/15-6/30/15, 3/24/18-5/18/18
Oral methotrexate 3/13/15 - 5/14/16 (15 mg weekly)
Clobetasol for Remicade-induced psoriasis
03-06-2018, 03:45 PM   #3
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Very interesting! Our GI prefers pillcams, but it seems like MREs are done more. She said it can be hard to get some insurance companies to cover pillcams that are not done for diagnostic purposes and that was our experience.

Our insurance company did not initially cover it since my daughter was already diagnosed, but after appealing and fighting with them, they did cover most of it.
Mom of M (20)
diagnosed with Crohn's Disease at 16
Juvenile Idiopathic Arthritis at 12
Juvenile Ankylosing Spondylitis at 16

Mom of S (23)
dx with JIA at 14
Ankylosing Spondylitis at 18
03-06-2018, 04:37 PM   #4
my little penguin
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MRE show scar tissue and thickening fistula etc...
Which can’t be seen at all on a pill cam
Pill cam can see ulceration but can take biopsy of normal looking tissue
Both aspects are important part of understanding where the disease is at and how it progresses
DS - -Crohn's -Stelara -mtx
03-10-2018, 10:19 PM   #5
Lady Organic
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Location: Quebec

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I thought these exams would have much higher accuracy and precision, I am quite surprised... This means a lot of sick people undergo these exams and fail to get a diagnosis. Thats pretty sad.
''UC-like Crohn's'' since 2001:
on: 25mg 6-MP (purinethol)+ B12 shots
minor hands/wrists chronic arthritis since 01/2013

Diet: ''IBD-AID'' : organic food only
suppl Curcuminoid extract, Inulin,psyllium, apple pectin, Vitamin D

past meds:
pred 50mg, 5-ASA, cortifoam, Imuran (failed) Purinethol (success) methotrexate (failed CD and arthritis).

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