Crohn's Disease Forum » Treatment » 5-ASA/Mesalamine » Drugs other than Asacol

03-26-2010, 12:45 PM   #1
Join Date: Jan 2009
Location: Toledo, Ohio
Drugs other than Asacol

Are there any other drugs that are a step up from asacol, other than humira, cimzia, remicade or any of those.
03-26-2010, 01:28 PM   #2
Senior Member
Join Date: Mar 2010
I think prednisone and immunosuppressants like Azathioprine or 6-MP are the next step followed by methotrexate.
03-26-2010, 01:54 PM   #3
Join Date: Jan 2009
Location: Toledo, Ohio
I already told my GI that I am not ever going to take prednisone. I took that before and did not like the side effects at all. He mentioned humira, cimzia, and remicade, but did not mention azathioprine or 6mp or methotrexate.
03-26-2010, 02:05 PM   #4
My Butt Hurts
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Join Date: Aug 2007
Yeah - I would have said 6-mp or Imuran too.
The trouble with those is that they typically take 3 months to start working.
It is possible that a similar drug to asacol would help you. Sulfasalazine was my first drug, and then I was moved to asacol. When asacol quit, I took pentasa with good results for a few years. There are several different 5-asa (I think they are called that) drugs.
Maybe you could try entocort instead of prednisone? It's similar, but a bit weaker I guess? My doc wouldn't let me take it instead of pred becasue it wasn't as strong, but many members here have had good luck with it.
03-26-2010, 02:09 PM   #5
Senior Member
Join Date: Mar 2010
They usually do the prendisone until the aza or 6 mp kick in. Maybe they would just keep you on asacol until the aza or 6 mp kick in.
03-26-2010, 02:49 PM   #6
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Join Date: Jan 2010
Location: St Helens, Merseyside, United Kingdom

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Yes Kirkland
we call it Budesonide here in Uk - a steroid but not as strong
Imuran is Aza here
IMO - Pentasa is not strong enough on it's own, too mild


Dx Crohn's in TI 2005 symptoms for 15 years prior

BEEN ON -Azathioprine, 6MP, Prednisolone, Pentasa, Budesonide, Metronidazole, Humira, Methotrexate,

NOW ON -Amitriptyline 25mg
21/02/14 Right hemicolectomy surgery!/profile.p...4208290&ref=ts

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03-26-2010, 07:24 PM   #7
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Join Date: Aug 2009
it seems worth mentioning that these drugs being discussed are very different in the approach to treatment.

The 5 ASA drugs are a fancy aspirin. They reduce swelling at the site of absorption. 5ASA drugs were hopefuls that turned out to be less effective than expected. Asacol/Pentasa/Salofalk

Steroids like Prednisone suppress the immune system a bit by limiting the abilities of white blood cells. They reduce inflammation fast and are suitable for short term treatment to get a flair under control quickly.

Imuran/6mp is a long term immune suppression drug that reduces your ability to produce white blood cells. Very cost effective treatment.

Humira/Remicade are TNF blockers that use modified biological agents to reduce your bodies ability to produce inflammation. These are comparatively expensive long term treatments.
Rectum? Damn near Killed'em

Diagnosed July of 2009 / Surgery Oct 2009 / 175mg Imuran since Jan 2010
03-26-2010, 08:14 PM   #8
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Join Date: Jul 2008
Location: California

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I took Entocort after Asacol and didn't have any issues.
Currently on: Colazal, Prilosec, multi-vitamin, probiotics, total EFA's, glucosamine.

Previous meds: Sulfasalazine, Asacol, Rowasa, Pentasa, Entocort.

"Adopt the pace of nature: her secret is patience. -Ralph Waldo Emerson"
03-27-2010, 11:03 AM   #9
Join Date: Jan 2009
Location: Toledo, Ohio
I am currently tapering off of entocort and I'll keep taking the asacol. I still have blood in my stool, but my GI doesn't seem concerned about it as long as I am not in pain. I guess he thinks the entocort will not get rid of the blood. I was only on the entocort for about 6 weeks, he doesn't want me to take it longer than that, I really don't know why.

Crohn's Disease Forum » Treatment » 5-ASA/Mesalamine » Drugs other than Asacol
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