I've been on LDN since about December 2016. I don't know that I'd call it smooth sailing, but I'm doing okay. I'm trying to get off of prednisone so I've had some issues with that - it turns out I have to taper verrry sloooowly (by 0.5 mg once per month) or I flare up again. I've also had a lot of stress in my life lately which isn't making my guts feel great (my job situation is tenuous and stressful, and my dog was recently diagnosed with terminal cancer). So, I'm okay for the most part, but it hasn't necessarily been smooth sailing.