6-TG is a drug occasionally used when treatment with Azathioprine or 6-MP is not tolerated. The body converts 6-TG directly to 6-tgn so it bypasses some of the potential toxic effects of Azathioprine and 6-MP. However, 6-TG has its own set of serious side effects such as Nodular Regenerative Hyperplasia (NRH) so at present, it is not widely utilized or recommended.[1]


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