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ANCA - Anti Neutrophil Cytoplasmic Antibodies Test

Anti Neutrophil Cytoplasmic Antibodies Test - ANCA

The Anti Neutrophil Cytoplasmic Antibodies Test, or ANCA, is part of the Prometheus IBD sgi Diagnostic used to indicate whether a patient has Crohn's Disease (CD) or Ulcerative Colitis (UC).

The ANCA tests for the presence of Antibodies that are specific for the granules in neutrophil cells.

A positive ANCA test indicates the patient may have Ulcerative Colitis.
Positive ANCA Subtypes
Within a positive ANCA test result there may be different patterns:

- (c)ANCA - Cytoplasmic ANCA - ANCA staining pattern is throughout the non-nuclear portion of the cell.

- (p)ANCA - Perinuclear ANCA - ANCA staining pattern is surrounding the nucleus or on the periphery of the nucleus.

- (x)ANCA - Atypical ANCA - ANCA staining pattern of the nuclear periphery which diffuses into a portion of the cytoplasm.

In IBD patients, the (p)ANCA or (x)ANCA staining patterns are typically present.

The positive ANCA result is confirmed by a negative result after DNAse (deoxyribonuclease) treatment.

A positive (p)ANCA test may precede onset of disease in asymptomatic persons. [3]


1. Jaskowski TD, Litwin CM, Hill HR. Analysis of Serum Antibodies in Patients Suspected of Having Inflammatory Bowel Disease. Clin Vaccine Immunol.2006; 13 (6):655-660.

2. Bossuyt X. Serologic markers in inflammatory bowel disease. Clin Chem. 2006;52(2):171181.

3. Israeli E, Grotto I, Gilburd B, et al. Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease. Gut. 2005;54(9):12321236.

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