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Achlorhydria / Hypochlorhydria


Achlorhydria / Hypochlorhydria

What are Achlorhydria and Hypochlorhydria

Achlorhydria Defined

- Achlorhydria is a condition where there is no stomach acid (gastric acid) production.

Hypochlorhydria Defined

- Hypochlorhydria is the condition in which only low amounts of stomach acid is produced.

Achlorhydria / Hypochlorhydria in Crohn's Disease

In people with Crohn's Disease, this is usually caused by acid blocking drugs such as Proton Pump Inhibitors (PPIs) or H2-receptor antagonists (H22-RAs) or gastritis. As vitamin B12 needs high levels of stomach acid to be separated from protein, this can result in vitamin B12 deficiency.

Hypochlorhydria can also increase the risk of developing Small Intestine Bacterial Overgrowth (SIBO).[1]

What Causes Achlorhydria / Hypochlorhydria

There are multiple factors that can cause a person to have Achlorhydria or Hypochlorhydria:

- Use of Proton Pump Inhibitors (PPI) - For example, Prevacid, Nexium, Protonix, Zegrid, Omeprazole, Dexilant, Prilosec, etc.

- Use of Antacids -

- Use of H2 Receptor Antagonists -

- Autoimmune disease that attacks the acid producing cells

- Helicobacter pylori infection

- Niacin Deficiency -

- Surgery - Gastric Bypass

- Low Thyroid

- Pernicious Anemia

- Inflammation of the Stomach

- Mucolipidosis [4]

How do Achlorhydria and Hypochlorhydria Affect Health

How do Achlorhydria and Hypochlorhydria Affect My Medication

- Itraconazole / Sporanox (AntiFungal Drug) is poorly absorbed in persons with low- or absent- stomach acid. [3][5][6] Attempts to treat a systemic fungal infection using Itraconazole in patients with Achlorhydria and Hypochlorhydria may be limited.


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