About Augmentin

Augmentin is an Antibiotic of the Beta - Lactam class.

Augmentin is a combination of the Antibiotic, Amoxicillin and Clavulanate Potassium or Clavulanic Acid.

The addition of Clavulanate helps to inhibit many Beta - Lactamases produced by bacteria which allow them to be Resistant to many Antibiotics in this class.

Absorbance and Tissue Distribution

Augmentin is well absorbed in the Gastrointestinal Tract.

Whether Augmentin is taken with or without food has little effect on Absorbance of the Amoxicillin portion of the Drug. However, the Clavulanate portion is reduced if taken with food (especially high fat foods).

Amoxicillin is well distributed in many tissues and body fluids except the brain and spinal fluid.

Types of Infection

Augmentin is mainly used to treat Aerobic bacterial infections as its efficacy against Anaerobic bacterial species is quite limited.

Augmentin has increased efficacy over Amoxicillin in that it can treat many Beta - Lactamase - producing (Resistant) bacterial strains.

Augmentin is useful in treating Infections of:
Lower Respiratory Tract
Urinary Tract

Augmentin is effective against a Broad Spectrum of Bacterial Species Including:
Bacteroides sp.
Enterobacter - Urinary Tract Infections
Enterococcus faecalis
Escherichia coli - Skin and Urinary Tract Infections
Fusobacterium sp.
Haemophilus influenzae - Ear, Lower Respiratory and Sinus Infections
Klebsiella sp. - Skin and Urinary Tract Infections
Moraxella catarrhalis - Ear, Lower Respiratory, and Sinus Infections
Staphylococcus aureus - Skin Infections
Staphylococcus epidermidis
Staphylococcus saprophyticus
Streptococcus pneumoniae
Streptococcus pyogenes
Streptococcus viridans

Augmentin Warnings and Side Effects

Warnings / Precautions

The possibility of an Allergic Reaction or Hypersensitivity may occur when taking any medication. This includes Antibiotics, such as Augmentin. If you have had a reaction or known allergy to Augmentin or Amoxicillin in the past, make certain all of your doctors and nurses know of the reaction.

Augmentin should be used with caution in patients with Liver Disease.

Reactions to Antibiotics, including Augmentin, Life Threatening. Augmentin has a low level of toxicity when compared to other types of Antibiotics. However, Severe and Life Threatening Reactions can Include, but are not limited to:
Allergy / Hypersensitivity
Antibiotic Associated Diarrhea - AAD
Asthma / Bronchospasm
Blood Pressure Loss
Clostridium difficile Infection
Pseudomembranous Colitis
Rash / Skin Lesions / Loss of Skin
Toxicity to Heart, Kidney or Liver

Side Effects

Augmentin can be used in Adults or Children and is often well-tolerated by patients.

The most Frequently Reported Side Effects Are:
Diarrhea (9%)
Nausea (3%)
Rash (3%)
Vaginitis (1%)
Vomiting (1%)

The Occurance of side effects increases with higher doses.

Augmentin Effects on Fertility and Pregnancy

Augmentin and Fertility / Reproduction
There have been no well controlled studies on Augmentin in Pregnant women. Augmentin is only suggested for use in Pregnancy if "Clearly Needed".

Animal studies have shown no impairment of Fertility and Fetal Development, even at doses above those given in human patients. However, studies in animals do not always agree with what occurs in humans. Also, there have been no long-term studies on Reproductive Effects of Augmentin in Animals which may affect results.

Augmentin is a Pregnancy Category B Drug.

Augmentin and Female Hormones
Augmentin may decrease blood levels of certain types of Female Hormones. This may affect Pregancy and Reproduction.[1]

Augmentin and Labor / Delivery
Augmentin may decrease the duration and intensity of contractions during labor and may prolong its duration.[1]

Augmentin and Newborn Babies
Augmentin may increase the risk of Necrotizing Enterocolitis in Newborn Babies. Kidney function may be impair the elimination of Augmentin in babies younger than 12 weeks of age.

Augmentin and Nursing
Augmentin can be passed through milk. Caution should be exercised when using Augmentin in Nursing Mothers.

For More Information on Pregnancy Categories for Medications check out the Crohn's Forum Wiki Page: Pregnancy Categories for Drugs.

Augmentin Drug Interactions

Birth Control / Oral Contraceptives - As with other Antibiotics, Augmentin can reduce the Effectiveness of Oral Contraceptives.

Probenecid - (used as a treatment for Gout) can reduce kidney excretion of Augmentin[2]

Augmentin Laboratory Test Interactions

Anemia / Hemolytic Anemia
Increased Bleeding may be indicated by Increased Prothrombin Time (PTT) - Especially in patients also on Blood Thinner (Anticoagulant) Medication.
Low Platelet Counts (Thrombocytopenia)
Low White Blood Cell Counts (Leukopenia) - May be restricted to one type or multiple types.

Glucose / Sugar Testing by Urine - Some types of Urine tests for Glucose / Sugar can show a False - Positive result (test shows glucose when no glucose is present). Tests susceptible to False - Positive Result include: ClinitestR and Benedict's or Fehling's Solution based Tests.
-- Recommend using CliniStixR (or other Glucose Oxidase based testing kit).

Aspartate transaminase (AST) / Serum Glutamic Oxaloacetic Transaminase (SGOT) may be Elevated
Alanine Aminotransferase (ALT) / Serum Glutamic Pyruvate Transaminase (SGPT) may be Elevated

For More Information on Blood Tests and Normal Values check out the Wiki Blood Test Codes and Results Explained


AugmentinR (amoxicillin / clavulanate potassium). Updated April 2008. Accessed October 2012.

Probenecid. PubMed Health. Updated September 2010. Accessed October 2012.

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