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Celexa - Citalopram Hydrobromide

Celexa, in generic form citalopram hydrobromide, is an antidepressant classified as an SSRI (selective serotonin reuptake inhibitor). Recently, the FDA has issued a Warning regarding Celexa's involvement in problems with the electrical activity of the heart, called Prolonged QT. Prolonged QT syndrome can be dangerous and can cause a type of fast heart rate called Torsade de Pointes.[1]

These warnings include (but are not limited to):
- Celexa should not be prescribed at dosages above 40mg per day.
- Celexa should not be used in persons with long QT, bradycardia, hypokalemia (low blood Potassium), Hypomagnesaemia (low blood Magnesium), recent heart attack, or heart failure.
- Celexa should not be used in other drugs that cause prolonged QT of the heart.
- Celexa should not be prescribed at doses above 20mg per day in patients with certain liver problems, older than 60 years, taking Tagamet (cimetidine), patients that are CYP2C19 "poor metabolizers" or are taking another drug that inhibits the enzyme CYP2C19.
- These conditions limit the ability of the body to clear Celexa before the next dose and can potentially increase the amount of Celexa in the body to unsafe levels.


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