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IL1B - Interleukin 1-beta

- Interleukin 1-beta, IL1B, is a Cytokine involved in the Inflammatory Response.

- IL1B increases inflammatory-activated hypersensitivity to Pain, or Hyperalgesia.

- IL1B is expressed following NOD2 / CARD15 Gene activation at higher levels in cells with ATG16L1 - Autophagy Related 16 Like 1 mutation (*300A) than cells with non-mutated ATG16L1.

- IL1B is also associated with Osteoarthritis (OA), Osteoperosis, Cell Proliferation, and Cell Differentiation.

- IL1B can be induced by Aluminum.

Other Cytokines in IBD

Check out the Wiki page listing other Cytokines involved in IBD HERE.

Popular Threads Discussing IL1B - Interleukin 1-beta

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04-11-2012, 09:25 PM   #1
David's Avatar
Join Date: Feb 2006
Location: Naples, Florida
I was just reading about Methotrexate and it said, "Methotrexate results in impaired DNA synthesis and IL-1 inhibition"

Would that be this IL1B or are there other IL1's it may inhibit? I'm not educated on Interleukin stuff yet
It's good to be back
04-12-2012, 12:35 AM   #2
Senior Member
handle's Avatar
Join Date: Feb 2011
There was only Interleukin-1 to begin with....
Then it was found that there were actually two proteins, IL-1alpha and IL-1beta, plus an IL-1 receptor antagonist (inhibitor) involved.
After that another 7 members of the IL-1 cytokine (signalling) family were added. They have all now been renamed as IL-F1 to IL-F10.
Both IL-F1 (previously called alpha) and IL-F2 (previously known as beta) are involved in the mediation of inflammatory response, produced by activation of macrophages.
Methotrexate has been shown to decrease the binding ability of interleukin 1 beta to the interleukin 1 receptor.

Last edited by handle; 04-12-2012 at 01:20 AM.
04-12-2012, 10:55 AM   #3
David's Avatar
Join Date: Feb 2006
Location: Naples, Florida
It gets more complicated all the time Thanks handle!
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