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Mastocytic Enterocolitis

Mastocytic Enterocolitis is a "new" form of Inflammatory Bowel Disease (IBD) that is not tested for (or even known about) by all Gastroenterologists. It is diagnosed by the presence of increased mast cells via intestinal biopsy.



Abdominal pain, diarrhea, bloating, constipation, headaches, skin rashes, bladder spasms, pelvic pain, muscle and Joint Aches, Arthritis, and Fatigue.


Mast Cells are not routinely stained when examining intestinal biopsies. In order for diagnosis to occur, the Gastroenterologist has to suspect the possibility of Mastocytic Enterocolitis and request the stain for mast cells be performed. The intestines may look completely normal upon colonoscopy. Elevated serum tryptase may also help lead to diagnosis.[1]

What are Mast Cells

Mast cells are immune system cells found throughout the body that contain a variety of chemicals such as leukotrienes, eosinophilic, histamine, chemotactic factor, interferon, and interleukin. They fight infections, recruit other cells to help fight infections, and even help regulate nerve signals.


Mast cells release massive amounts of histamine so multiple forms of antihistamines (H1 and H2) are usually prescribed and leukotriene blockers like Singulair and mast cells stabilizers such as Gastrocrom (cromolyn sodium).

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