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PANCA (peripheral antineutrophil cytoplasmic antibodies) Test

pANCA - Peripheral Anti-Neutrophil Cytoplasmic Antibodies

The pANCA test, or test for "atypical" peripheral anti-neutrophil cytoplasmic antibodies, is performed as part of the Prometheus IBD sgi Diagnostic (Prometheus Therapeutics & Diagnostics) used to differentiate/diagnose inflammatory bowel disease (IBD) vs. non - IBD, Crohn's Disease (CD), and Ulcerative Colitis (UC).

- pANCA can be used to support a diagnosis of IBD or asan aid in distinguishing UC from CD but should not be used to diagnose IBD

- pANCA staining pattern is due to autoimmune antibodies specific to neutrophil granules.

- DNAse sensitive pANCA, or the loss of this autoantibody pattern upon treatment with DNAse enzyme is typically seen in UC patients.

- The pANCA test is also used to help diagnose multiple other conditions and should not be used as a sole marker for diagnoses of IBD.

- pANCA are typically used in IBD patients to help differentiate between CD and UC as increased pANCA results are more often seen in UC patients (30%-83%) than in CD patients (6%-20%) and controls (2.5%).

- DNAse sensitive pANCA, or the loss of


1. Papp M, Altorjay I, Dotan N et al. New Serological Markers for Inflammatory Bowel Disease Are Associated With Earlier Age at Onset, Complicated Disease Behavior, Risk for Surgery, and NOD2/CARD15 Genotype in a Hungarian IBD Cohort. Am J Gastroenterol. 2007;102:1-17.

2. Papp M, Altorjay I, Norman GL, et al. Seroreactivity to microbial components in Crohn’s disease is associated with ileal involvement,noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a hungarian cohort of IBD patients. Inflamm Bowel Dis. 2007;13(8):984-992.

3. Peeters M, Joossens S, Vermeire S, et al. Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease. Am J Gastroenterol. 2001;96:730-734.

4. Prometheus Monograph.

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