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PML - Progressive Multifocal Leukoencephalopathy

Progressive Multifocal Leukoencephalopathy, or PML, is a rare brain infection that destroys the white matter of the brain [2] and often causes severe disability or death. There is no treatment or cure for PML.[1][2]

Risk factors that increase chances of getting PML are:
- Administration of Tysabri. Especially long-term administration of Tysabri (over 2 years)
- Weakened Immune System (due to disease, genetics, or immunosuppressant drugs)
- Exposure to John Cunningham Virus (JCV)

Symptoms of PML are:
- Headache [2]
- Vision or Memory loss [2]
- Progressive weakness of the arms or legs [2]
- Loss of coordination or language [2]


1. Patient Guide to Important Tysabri Information

2. Progressive multifocal leukoencephalopathy (PML)

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