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Proton Pump Inhibitors (PPI)


Proton Pump Inhibitors (PPI)

Proton Pump Inhibitors (PPIs) are prescribed to lessen the amount of stomach acid that is produced. Lower levels of stomach acid can give the opportunity for ulcers or inflammation in the stomach and small intestine to heal.

Caution in Long Term Use of PPIs

Long term use of PPIs have been correlated with Hypomagnesemia, or low levels of serum magnesium, especially when taken in combination with other drugs known to lower serum magnesium levels such as, Digoxin, Diuretics, etc.[1]

Low serum Magnesium levels can have dangerous side effects including: irregular heartbeat (arrhythmia), siezures / convulsions, and muscle spasms.

Decreased levels of stomach acid can interfere with the absorbtion or other medications or certain Vitamines and Minerals such as vitamin B12 which people with Crohn's Disease are at great risk of being deficient in.

Drugs Classified as (or Containing) Proton Pump Inhibitors (PPIs)

- AcipHex (rabeprazole sodium), Eisai Inc. and Janssen Pharmaceuticals, Inc;

- Dexilant (dexlansoprazole), Takeda Pharmaceuticals;

- Nexium (esomeprazole magnesium), AstraZeneca;

- Prevacid 24HR (lansoprazole), Takeda Pharmaceuticals U. S. A., Inc;

- Prevacid (lansoprazole), Takeda Pharmaceuticals U. S. A., Inc;

- Prilosec (omeprazole), AstraZeneca;

- Prilosec OTC (omeprazole), AstraZeneca;

- Protonix (pantoprazole sodium), Pfizer;

- Vimovo (esomeprazole magnesium with naproxen), AstraZeneca;

- Zegerid (omeprazole and sodium bicarbonate), Santarus Inc.;

- Zegerid OTC (omeprazole and sodium bicarbonate), Santarus Inc..



2. Dean L. Comparing Proton Pump Inhibitors. PubMed Health. Oct 2010, Accessed May 2012.

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