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Sclerosing Cholangitis

About Sclerosing Cholangitis

Sclerosing Cholangitis can refer to:
Primary Sclerosing Cholangitis, or PSC, which is Sclerosing Cholangitis with no known cause;


Secondary Sclerosing Cholangitis, SSC, which is Sclerosing Cholangitis due to many possible causes, including: Immune Deficiency, Infection, Chronic Biliary Inflammation, Ischemia, Chronic Bile Duct Obstruction, Medication or Toxins.

Sclerosing Cholangitis is a Chronic liver disease where Inflammation of the bile ducts causes scarring resulting in restricted flow of bile. It can ultimately lead to liver failure and require transplant. Seventy percent of PSC patients also suffer from [wiki=ibd]Inflammatory Bowel Disease (IBD), especially Colitis and up to five percent of Ulcerative Colitis (UC) patients may go on to develop PSC.

PSC is a very slowly progressing disease and many years may pass before symptoms appear. Symptoms may include severe itching caused by jaundice as well as malabsorption of fat soluble vitamins such as A,D,E and K. See Vitamin and Mineral Deficiencies

PSC patients should be screened for Cholangiocarcinoma (cancer of the bilary system).


Ursodiol (Actigall), believed to favorably change the make-up of bile in the liver.

Questran Powder for the itching, helps remove excess bile from the body by binding it in the gut where it is passed in the stool.

Balloon Dilation and stints to open restricted bile ducts.

Liver Transplant, currently over a 90% success rate with high quality of life afterwards.


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02-03-2013, 11:09 PM   #1
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Trysha's Avatar
Join Date: Aug 2009
Hello Judith
Thank you for this useful article.
It could be very helpful to patients suffering it and who feel it a very difficult
situation to deal with.
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