Crohn's Disease Forum » Forum Wiki » Sulfasalazine


Sulfasalazine, also known as SASP, is a preparation of 5-Aminosalicylic acid (5-ASA) - (or Mesalamine) - linked to Sulfur. In the Colon, Sulfasalazine is converted by bacteria into Sulfapyridine and the active drug, Mesalamine (5 ASA). It is used in the treatment of Ulcerative Colitis, a type of Inflammatory Bowel Disease (IBD).

Sulfasalazine compounds are more likely to cause side effects than 5-ASA medications but are less expensive. Sulfasalazine may be prescribed in patients where cost is a factor in treatment. In one study, 29% of patients experienced side effects with Sulfasalazine versus 15% of patients taking 5-ASA.[1]
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