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Sweet's Syndrome

Sweet's Syndrome, also known as Febrile Neutrophilic Dermatosis is a skin disease that is one of the potential extraintestinal manifestations of Crohn's Disease and other IBD. It is characterized by red lesions (spots) on various areas of the body. It is not uncommon for Sweet's Syndrome to occur before a diagnosis of IBD.



Fever (50% of cases), tiredness, aching joints, elevated alkaline phosphatase (83% of cases), raised white blood cell count (WBC), and tender, red papules, nodules, and plaques. The lesions are most commonly found on the back of fingers and hands but also commonly occur on the head, neck, legs, and arms. The trunk of the body is not commonly involved.

Pictures of Sweet's Syndrome


If a biopsy of a papule is taken, it should show dense infiltrates by neutrophil granulocytes upon examination. Occasionally Sweet's Syndrome is diagnosed as Erythema Nodosum.


Corticosteroids such as Prednisone are commonly used.


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